L-Leucine 99% 61-90-5 L Leucine

L-Leucine: A Vital Branched-Chain Amino Acid for Metabolic Health and Nutritional Support L-Leucine, a naturally occurring essential amino acid with the molecular formula C6H13NO2, is a cornerstone of protein synthesis and metabolic regulation in the human body. As one of the three branched-chain amino acids (BCAAs)—alongside L-isoleucine and L-valine—it plays a critical role in muscle repair, energy production, and nitrogen balance maintenance. First isolated from cheese by Proust in 1819 and later crystallized from hydrolyzed muscle and wool by Braconnot, this white, odorless compound exists as hexahedral crystals or a fine powder at room temperature. With a sublimation point of 145–148°C and a decomposition melting point of 293–295°C, it exhibits thermal stability under controlled conditions and remains soluble in dilute hydrochloric acid, alkaline solutions, and aqueous environments containing hydrocarbons. This pure form of L-leucine is not only crucial for dietary supplementation but also serves as a foundational ingredient in medical formulations such as amino acid infusions, parenteral nutrition solutions, and therapeutic preparations for metabolic disorders. It supports healthy glucose metabolism, making it particularly beneficial in managing idiopathic hyperglycemia in pediatric populations and addressing liver-related issues involving bile secretion deficiencies. Additionally, its use extends to treating conditions like anemia, muscular atrophy, post-polio syndrome, neuritis, and certain mental health concerns linked to amino acid imbalances. Key Features: - Chemically stable in acidic and neutral aqueous systems - Slightly soluble in ethanol (0.07%), fully soluble in dilute HCl and alkaline carbonate solutions - Non-toxic, non-irritating, and suitable for oral and injectable applications - Ideal for formulation in sports nutrition, clinical supplements, and plant growth enhancers In clinical settings, L-leucine is often combined with other essential amino acids to optimize recovery from trauma, chronic illness, or malnutrition. Its ability to stimulate muscle protein synthesis makes it especially valuable for athletes, older adults experiencing sarcopenia, and patients recovering from surgery or prolonged hospitalization. In agricultural contexts, it acts as a growth promoter for crops, enhancing yield and resilience through improved nitrogen utilization. Common Uses Across Industries: - Medical Nutrition: Used in IV amino acid solutions for critically ill patients - Sports Supplements: Added to pre- and post-workout formulas for enhanced recovery - Dietary Additives: Incorporated into fortified foods and beverages for daily intake support - Research Applications: Employed in biochemical studies on insulin signaling, mitochondrial function, and neuroprotection User Feedback: Health professionals frequently highlight L-leucine’s effectiveness in restoring normal metabolic pathways in individuals with impaired glucose tolerance. Patients report improved energy levels, reduced fatigue, and better muscle tone when integrated into personalized amino acid regimens. Researchers appreciate its purity and consistent performance in both in vitro and in vivo models, particularly for studying BCAA metabolism and insulin sensitivity. Frequently Asked Questions: What distinguishes L-leucine from other amino acids? Unlike non-essential amino acids, L-leucine must be obtained through diet or supplementation because the body cannot synthesize it. Its unique structure allows it to activate mTOR—a key regulator of protein synthesis—making it indispensable for tissue repair and muscle building. Is L-leucine safe for long-term use? Yes, when used within recommended dosages (typically 2.2 grams per day for adult men), L-leucine is well-tolerated and safe. Clinical trials have shown no significant adverse effects in healthy adults over extended periods. How does L-leucine benefit athletic performance? It enhances endurance by promoting glycogen sparing during exercise and accelerates recovery by reducing muscle breakdown and stimulating new protein formation. For those seeking a scientifically backed, high-purity source of this vital nutrient, L-leucine offers a versatile solution across healthcare, fitness, and nutritional science domains.