High purity cas 42971-09-5 99% Vinpocetine

Vinpocetine: A Potent Cerebral Circulation Enhancer and Neuroprotective Agent Vinpocetine, scientifically known as ethyl apovincaminic acid, is a white crystalline powder with no odor or taste, widely recognized for its ability to improve brain function following cerebrovascular events such as stroke, cerebral hemorrhage, and arteriosclerosis. This compound, derived from the natural alkaloid vincamine found in Vinca minor (a plant of the Apocynaceae family), undergoes chemical transformation through dehydration and hydrolysis to yield a highly bioactive derivative. With a molecular formula of C₂₂H₂₆N₂O₂, vinpocetine exhibits excellent solubility in organic solvents like chloroform and 96% ethanol while remaining nearly insoluble in water—making it suitable for pharmaceutical formulation and targeted delivery systems. Key Features: - High selectivity for cerebral vasodilation without systemic hypotensive effects - Proven enhancement of red blood cell flexibility and microcirculatory flow - Neuroprotective properties under ischemic conditions - Supports cognitive performance by improving glucose utilization and monoamine metabolism in the brain Detailed Description: This semi-synthetic compound acts primarily by inhibiting calcium-dependent phosphodiesterase activity, thereby increasing intracellular cyclic adenosine monophosphate (cAMP) levels—a key mediator in relaxing vascular smooth muscle. As a result, cerebral blood flow increases significantly, which is especially beneficial during periods of reduced oxygen supply due to vascular blockages or chronic degenerative changes. Additionally, vinpocetine reduces blood viscosity by enhancing erythrocyte deformability and suppressing platelet aggregation, promoting healthier circulation throughout the central nervous system. Its protective mechanism extends to metabolic support: it helps maintain ATP levels in neurons during hypoxic stress, limits lactic acid buildup, and prevents oxidative damage via lipid peroxide inhibition—effectively delaying neuronal dysfunction caused by ischemia. The compound’s stability under standard storage conditions makes it ideal for long-term shelf life when kept tightly sealed at room temperature. Its melting point ranges between 147–153°C, and it has a flash point of 207.5°C, indicating safe handling practices are straightforward for researchers and clinicians alike. The synthesis process involves refluxing apovincaminic acid with potassium hydroxide and ethyl bromide in dry ethanol—an efficient method yielding up to approximately 66% purity after purification steps including acidification, solvent extraction, and recrystallization. Applications Across Medical Fields: In neurology, vinpocetine is used to treat post-stroke deficits, memory decline, and dizziness associated with cerebral arteriosclerosis. In cardiology, it aids patients suffering from coronary artery disease and abnormal blood rheology. Ophthalmologists may recommend it for visual disturbances linked to poor ocular perfusion, while otolaryngologists use it off-label for tinnitus, hearing impairment, and vertigo stemming from inner ear circulatory issues. Post-neurosurgical rehabilitation also benefits from its role in supporting neural recovery and functional restoration. User Feedback: Healthcare professionals often report improved patient outcomes in terms of alertness, concentration, and balance within weeks of consistent administration. Many users note enhanced mental clarity and reduced fatigue, particularly those recovering from transient ischemic attacks or mild cognitive impairment. While not intended as a standalone treatment for dementia, clinical studies suggest it complements other therapies aimed at preserving brain health in aging populations. Frequently Asked Questions: Is vinpocetine safe for daily use? Yes, when taken as directed, it demonstrates low toxicity and favorable pharmacokinetics in adults over 18 years old. Can it be combined with other medications? Consult a healthcare provider before combining with anticoagulants or antiplatelet drugs due to potential additive effects on blood thinning. How soon can results be expected? Some individuals experience subjective improvements in focus and energy within 2–4 weeks; optimal neurological benefits typically require sustained use over 8–12 weeks. What is the recommended dosage? Dosage varies based on indication but commonly ranges from 10 mg to 30 mg per day, divided into two or three doses. Always follow medical guidance for personalized regimens. Vinpocetine stands out among nootropic agents not only for its specificity toward cerebral circulation but also for its multifaceted impact on cellular metabolism, antioxidant defense, and neuroplasticity. Whether used in clinical settings or as part of integrative wellness programs, this versatile compound remains a trusted ally in maintaining cognitive vitality and protecting against age-related neurological decline.