Odorless, tasteless; case of light yellowish yellowish heat, dissolved in chlo roform, slightly soluble in ethanol or ether, insoluble in water; soluble in dilute sulfuric acid. Luo Tong as antipyretic analgesics, clinically used mainly for the treatment of gastric ulcer and duodenal ulcer pain, menstrual pain, postpartum uterine pain, tension insomnia, spastic cough and so on.
Rotundine, also known as craniidine, L-tetrahydropalmatine, chemical name is 2,3,9,10-tetramethoxy-5,8,13,13a-tetrahydro-6H-dibenzo[a ,g] quinazine, the levorotatory of tetrahydropalmatine (dl-THP), is a blocker of dopamine receptors in the brain, and preferentially blocks the brain regions rich in dopamine receptors such as cortex and striatum.It also achieves analgesic effect by strengthening the function of the internal anti-pain system and inhibiting the transmission of pain information to the center.
Rotundine is an antipyretic and analgesic drug. It is mainly used in the treatment of gastric ulcer and duodenal ulcer pain, menstrual pain, post-partum contraction pain, tension insomnia, and spasmodic cough.
The Function of Rotundine
1. Analgesic effect: Rotundine has a significant analgesic effect. It can selectively block certain pain transmission pathways in the central nervous system, thereby reducing the perception of pain. It is particularly effective for mild to moderate pain. Can depress the chtonic persistent pain and splanchna dull pain.
2. Sedative and hypnotic effect: It has a certain sedative and hypnotic effect, which can help relieve anxiety and restlessness, and promote sleep. It can regulate the activity of the central nervous system and make the body in a more relaxed state.
3. Antispasmodic effect: It can relax smooth muscles and has a certain inhibitory effect on smooth muscle spasms, thereby relieving pain and discomfort caused by smooth muscle spasms.
4. Rotundine has the protective effect on liver injury induced by carbon tetrac hloride in mice.
5. Rotundine has effect of promoting blood circulation to remove blood stasis and promoting circulation of qi to relieve pain.
The Application scopes of Rotundine
Pain relief: It is used to relieve various types of pain, such as headache, toothache, neuralgia, menstrual pain, and postoperative pain. For example, in the case of mild to moderate headache and toothache, Rotundine can effectively alleviate pain symptoms.
Insomnia and anxiety: It is applicable to patients with insomnia and anxiety. By its sedative and hypnotic effect, it helps patients improve sleep quality and relieve anxiety, which is beneficial to the recovery of the body and mind.
Digestive system disorders: Due to its antispasmodic effect, it can be used in the treatment of some digestive system disorders accompanied by smooth muscle spasms, such as gastric and intestinal colic, helping to relieve pain and improve digestive function.
Traditional Chinese medicine and health care: In traditional Chinese medicine, Stephania sinica and its extract Rotundine have been used in some prescriptions for the treatment of related diseases. In the field of health care, it may also be used in some health products to help people relieve stress, improve sleep, and maintain physical and mental health, but its use in health products needs to comply with relevant regulations.
It should be noted that the use of Rotundine should be carried out under the guidance of a doctor to ensure safe and effective use.
