Npiper longum extract powder

Piper Longum Extract: A Potent Natural Compound with Multi-Functional Health Benefits Derived from the dried, near-mature or mature fruit of Piper longum L., a plant native to the Piperaceae family, Piper longum extract is a rich source of bioactive phytochemicals including piperine, palmitic acid, tetrahydro piperic acid, volatile oils, and polysaccharides. This fine brownish-yellow powder, 100% passing through an 80-mesh sieve, serves as a versatile ingredient across pharmaceuticals, nutraceuticals, cosmetics, and food industries due to its well-documented pharmacological properties. Key Features: - High-purity natural extract with standardized active constituents - Clinically supported anti-inflammatory, antioxidant, and hypolipidemic effects - Proven efficacy in supporting gastric mucosal integrity and immune modulation - Ideal for functional food development and dermatological formulations Detailed Description: Piper longum extract exhibits a broad spectrum of biological activities rooted in its complex chemical profile. Its ethanol and chloroform fractions demonstrate significant anti-inflammatory potential by reducing inflammatory cell infiltration—particularly neutrophils, eosinophils, and lymphocytes—and downregulating pro-inflammatory cytokines such as IL-4 and IL-5 while enhancing IFN-γ expression. The extract also inhibits adhesion molecules like ICAM-1, VCAM-1, and E-selectin on endothelial cells, thereby suppressing NF-κB signaling pathways involved in chronic inflammation. For metabolic health, piperine enhances lipid metabolism by upregulating HMG-CoA reductase, CYP7A1, LCAT, and LDL receptor expression, effectively lowering serum triglycerides and total cholesterol while boosting HDL levels in hyperlipidemic models. Antitumor activity has been observed against diverse cancer cell lines including HepG2, HeLa, SKOV-3, PC3, A549, and MCF7, primarily through piperine-induced cell cycle arrest, apoptosis, ROS elevation, and STAT3 pathway inhibition. Additionally, the extract demonstrates strong antioxidant capacity via scavenging ABTS and DPPH radicals, increasing SOD, CAT, and GSH-PX enzyme activities, and reducing malondialdehyde (MDA) levels in both experimental and animal models. Gastric protection is further enhanced by elevated serum gastrin (GAS) and mucosal PGE2 levels alongside suppressed TNF-α and IL-8 concentrations—key markers in gastric inflammation. The volatile oil component contributes to antibacterial and antiviral properties, offering promising applications in topical and systemic therapies. Applications: In modern medicine, Piper longum extract features prominently in traditional Chinese patent medicines such as Weitong Granules for epigastric discomfort associated with cold stagnation. When combined with herbs like sorghum or fragrant herb, it aids in treating stomach pain; paired with Xixin and Baizhi, it addresses dental discomfort. As a dietary supplement, its lipid-lowering and free radical-scavenging abilities make it suitable for managing hypercholesterolemia and promoting cellular longevity. In skincare formulations, this extract helps combat acne-causing bacteria, reduce redness, delay skin aging, and improve overall skin resilience—ideal for anti-acne, anti-wrinkle, and soothing creams. Within culinary contexts, the extract functions as a natural flavor enhancer and deodorizer, particularly effective in braised dishes where it improves aroma and masks undesirable odors from meat products. User Reviews: Users report improved digestion after incorporating Piper longum-based supplements into their routine, especially those experiencing bloating or mild gastric irritation. Skincare consumers note reduced breakouts and firmer skin texture over time when using products containing this botanical extract. Many appreciate its ability to provide gentle yet effective support without harsh synthetic ingredients. Frequently Asked Questions: What makes Piper longum extract different from black pepper? While both contain piperine, Piper longum offers additional compounds like sesamin and unique polysaccharides that enhance its antioxidant and anti-inflammatory effects beyond what is typically found in black pepper extracts. Is it safe for daily use? Yes, clinical studies indicate safety at recommended dosages, though individuals with sensitive gastrointestinal systems should start with lower amounts. Can it be used in vegan or clean-label products? Absolutely—it’s naturally derived, non-GMO, and compatible with vegetarian and organic certification standards. How does it benefit skin health? Through its antimicrobial, anti-inflammatory, and free radical-neutralizing actions, it supports clearer, more resilient skin, particularly beneficial for acne-prone or aging skin types.