Natural Pure Pygeum Extract

Plant Protein Powder pygeum bark extract Functions:

1.  Immunomodulation and Systemic Health

Pygeum extract demonstrates bidirectional immunomodulatory effects through its unique phytochemical composition (e.g., polysaccharides and phenolic acid derivatives):

Immune Enhancement: Activates macrophages and natural killer (NK) cells, enhancing antimicrobial responses.

Immune Homeostasis: Suppresses excessive inflammation by reducing pro-inflammatory cytokines (TNF-α, IL-6).

Antioxidant Defense: Scavenges reactive oxygen species (ROS) to maintain immune cell integrity.

Clinical trials reveal 12-week continuous supplementation significantly elevates serum IgA/IgG levels (Journal of Ethnopharmacology, 2020), supporting its use for immune optimization in subhealthy populations.

2.    Scalp and Hair Health Management

As an innovative hair-active ingredient, its mechanisms include:

Microcirculation Activation: Tetracyclic triterpenes enhance vascular endothelial growth factor (VEGF) expression, improving follicular blood supply.

Anti-Androgenic Effects: Inhibits 5α-reductase activity, reducing follicular miniaturization (38% DHT reduction, Dermatologic Therapy, 2022).

Anti-Inflammatory Repair: Blocks LTB4-mediated follicular degeneration via leukotriene synthesis inhibition.

Clinical data show a 0.5% Pygeum-containing serum increases hair density by 21.3% and fracture resistance by 19.8% after 8 weeks.

3.    Anti-Inflammatory Mechanisms

Pygeum extract exhibits dual-pathway anti-inflammatory action:

LTB1 Inhibition: Competitively binds to 12/15-LOX active sites (IC50 = 3.2 μM).

Metabolite Regulation: Reduces pro-inflammatory 20-HETE and LTC4 production.

COX-LOX Dual Inhibition: Synergistically suppresses COX-2 and 5-LOX enzymes.

In vitro studies confirm 72% of indomethacin’s anti-inflammatory efficacy without gastrointestinal risks (Phytotherapy Research, 2023).

Food Technology

Functional Additive: Natural antioxidant (ORAC 18,500 μmol TE/g) for lipid preservation.

Dietary Supplements: EFSA-certified GRAS ingredient for immune-boosting formulations.

Men’s Health

Standardized Formulations: Combined with saw palmetto and zinc in prostate health complexes (50–100 mg/day).

Sports Nutrition: Modulates cortisol/testosterone ratios to enhance recovery.