sodium dichloroacetate price DCA sodium dichloroacetate

Basic Introduction

Sodium dichloroacetate is a mitochondrial pyruvate dehydrogenase kinase (PDK) inhibitor with potent anti-leukemia activity. Sodium dichloroacetate is a metabolic regulator in cancer cell mitochondria with anti-cancer activity. The substance inhibits pyruvate dehydrogenase kinase (PDHK), resulting in a decrease in lactate in the tumor microenvironment. In addition, it increases the production of reactive oxygen species (ROS) and promotes apoptosis of cancer cells, and can also act as an NKCC inhibitor.

 

Uses

Sodium dichloroacetate can be used as a basic chemical in inorganic chemistry, it can be used as an organic salt precursor for the synthesis of microporous carbon, it can be used to develop carbon-based adsorbents, and the substance can also be used as a sodium carboxylate salt in the field of chemical synthesis. In addition, sodium dichloroacetate has been used as a drug for the treatment of congenital mitochondrial diseases, and the research done by Peter Staple and his colleagues has shown that sodium dichloroacetate does not cause any, mild or moderate side effects when used to treat congenital mitochondrial diseases.

 

Directions for use

If patients are currently using cannabinoids, benzodiazepines, opioids, or other drugs that affect the central nervous system, keep in mind that DCA can amplify adverse effects caused by these drugs (e.g., delirium, memory problems). This is more likely to happen if the prescription is already causing side effects. DCA appears to have a positive effect on heart function without creating an additional demand for oxygen. It also improves the efficiency of energy production in the heart muscle. The drug can be safely used in people with heart failure and increased risk of cardiac ischemia. Diabetic patients can achieve better blood sugar control with the help of sodium dichloroacetate, which appears to lower blood sugar between meals.