The full name of NMNH is "Reduced β - Nicotinamide Mononucleotide", which is the reduced form of NMN. The molecular formula of NMNH is C11H17N2O8P, with a molecular weight of 336.23g/mol, CAS No.：108347-85-9， It is an amorphous yellow powder. The latest research literature shows that NMNH increases NAD+levels faster and at higher concentrations, averaging 5 times higher than NMN. NMNH has achieved industrial development, with a purity of ≥ 99% and two forms: free acid and sodium salt.
The Function of NMNH
Quickly enhance in vitro NAD+
Compared to NMN, NMNH not only significantly increases the level of NAD+in cells, but also accelerates the rate of increase in NAD+concentration.
NMNH acts as an effective NAD+enhancer in vitro.
Adding NMNH can increase the NAD+content in cells and is more effective than NMN at the same concentration.
Increase NAD+concentration in the body
NMNH can effectively increase the concentration of NAD+in the blood, and can quickly increase NAD+levels within 1 hour of supplementation, which is much higher than NMN. It is worth noting that after supplementing with NMN, the NAD+concentration in the blood drops to the baseline level after 4 hours, but NMNH can maintain an increase of more than twice the NAD+concentration within 20 hours after the first injection.
Compared with NMN, NMNH can increase NAD+levels in various tissues, with the liver (5-fold increase) and kidneys (2-fold increase) having the greatest impact. Surprisingly, NMNH also significantly increased the levels of NAD+in the brain, gastrocnemius muscle, brown adipose tissue, and heart, which NMN cannot achieve.
Repair of tubular epithelial cells
The NAD+homeostasis is crucial for repairing damaged epithelial cells and maintaining cell biological activity. Researchers have specifically observed whether NMNH can protect tubular epithelial cells from hypoxia/reoxygenation damage by enhancing repair effects.
In a normoxic environment, supplementing with the same concentration of NMNH and NMN can increase the concentration of NAD+by 5 and 2 times, respectively; In hypoxic/reoxygenated environments, NMNH and NMN can increase higher NAD+concentrations.
After analysis, supplementing NMNH can reduce cell damage in hypoxia/reoxygenation injury and enhance cell repair ability by targeting NAD+regeneration, enhancing mitochondrial activity and nucleotide metabolism.
The COA of NMNH
