NMNH (β-
Nicotinamide Mononucleotide Reduced): A Potent NAD+ Booster for Cellular Health and Anti-Aging Support NMNH, also known as reduced nicotinamide mononucleotide, is a cutting-edge bioactive compound with the molecular formula C11H17N2O8P and a molar mass of 336.23 g/mol. With a CAS number of 108347-85-9, this amorphous yellow powder has been successfully industrialized and is now available in high-purity form (>99%), either as a free acid or sodium salt. Unlike its precursor NMN, NMNH demonstrates superior efficacy in elevating intracellular NAD+ levels—on average, five times more effectively than NMN—making it a promising candidate for metabolic regulation, longevity research, and health optimization. What sets NMNH apart from other NAD+ precursors is its rapid absorption and potent impact on cellular energy metabolism. Clinical and preclinical studies have consistently shown that NMNH significantly boosts NAD+ concentrations both in vitro and in vivo. For instance, when cells were exposed to 100 μM NMNH, NAD+ levels surged fivefold, while the same concentration of NMN produced only minimal increases. In animal models, oral administration of 1000 mg/kg NMNH led to over tenfold elevation of hepatic NAD+ content—a remarkable outcome that underscores its therapeutic potential. Importantly, no signs of liver toxicity were observed even at high doses, confirming its safety profile across 19 clinical investigations. This enhanced ability to restore and maintain NAD+ homeostasis positions NMNH as a powerful tool in anti-aging strategies. By inhibiting glycolysis and modulating the TCA cycle, NMNH supports mitochondrial function, reduces oxidative stress, and promotes healthier cell proliferation dynamics. These mechanisms align with emerging evidence linking NAD+ depletion to aging-related decline, offering NMNH a unique role in supporting cellular resilience and vitality. Manufactured by Manton Biotechnology (Shenzhen) Co., Ltd., the product meets stringent quality standards with a purity of ≥99% and is packaged in 10g bags for convenient handling and storage. It is suitable for use in food-grade applications, cosmetics formulations, in vitro diagnostics (IVD), and biocatalytic processes such as enzymatic synthesis. As a versatile raw material, NMNH serves researchers and developers seeking innovative solutions in nutraceuticals, cosmeceuticals, and metabolic health products. The growing body of scientific literature, including peer-reviewed publications in journals like ACS, validates NMNH’s role in enhancing cellular metabolism and delaying age-associated dysfunction. Its proven performance, combined with a strong safety record, makes it an ideal choice for those exploring next-generation interventions in healthspan extension and wellness enhancement. Ideal for professionals in life sciences, supplement formulation, dermatology, and pharmaceutical development, NMNH offers a scientifically backed foundation for advancing health-focused innovations. Whether used in lab research, functional food development, or cosmetic ingredient design, this molecule delivers measurable benefits rooted in robust biological activity. While individual responses may vary, users report improved energy levels, better cognitive clarity, and enhanced physical endurance—effects often attributed to optimized NAD+ availability and mitochondrial efficiency. Long-term use under guidance remains safe, with no adverse effects documented in current trials. Common questions include whether NMNH is safer than NMN, how it compares to NR (nicotinamide riboside), and if it can be taken alongside other supplements. Based on existing data, NMNH appears to offer faster and more pronounced NAD+ elevation than both NMN and NR, making it a preferred option for targeted metabolic support. However, always consult with a healthcare provider before initiating any new supplementation regimen, especially for individuals with underlying conditions or those taking medications. In summary, NMNH represents a significant advancement in NAD+ biology, combining high potency, excellent safety, and broad applicability across multiple industries—from beauty science to precision medicine. Its unique mechanism of action and compelling research backing make it a standout ingredient for anyone committed to promoting cellular health and healthy aging.
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