Hesperetin is a natural flavonoid compound that is widely found in plant-derived substances such as fruits, flowers, and foods. Its main source is the hydrolysis of hesperidin. It has biological and pharmacological activities and is widely used in organic chemistry, medicine, agronomy, food, and other fields.
The Function of Hesperetin (1) Antioxidant effect: Hesperetin can avoid the harm caused by peroxidation by removing peroxynitrite ions.
(2) Anti-inflammatory effect: Hesperetin can inhibit the mediation of inflammatory mediators, thereby indirectly inhibiting inflammatory reactions. Compared with hesperidin, hesperetin has a stronger anti-inflammatory effect. The anti-inflammatory activity of hesperetin C7 is affected by the connection of rutin.
(3) Hypolipidemic effect: Hesperidin can inhibit the action of cholesterol-forming enzymes and esterification enzymes, thereby achieving the effect of lowering blood lipids.
(4) Cardiovascular protective effect: Hesperidin has the effect of lowering blood lipids and vascular permeability, and can prevent thrombosis. Hesperidin can also protect the hypoxia of endothelial cell tissue by stimulating certain mitochondrial enzymes such as succinate dehydrogenase, preventing coagulation caused by endothelial cell necrosis and inducing thrombosis. In addition, hesperidin promotes antiplatelet coagulation activity by inhibiting the phosphorylation of PLCγ2 and its downstream signal transduction, which can prevent the formation of thrombus and benefit the cardiovascular system.
(5) Anti-tumor effect: Hesperidin has an antioxidant effect, which can avoid carcinogenesis caused by genetic changes caused by these factors. It promotes the outflow of drugs mediated by P-glycoprotein from tumor cells. Flavonoids (such as hesperidin) can change the permeability of the blood-brain barrier to vincristine, which is also related to its concentration. Low concentrations of flavonoids can reduce the uptake of vincristine by brain capillary endothelial cells; conversely, high concentrations can promote it.
Market prospects Foreign market situation: (1) Hesperidin is used in health care drugs and health care products. For example, Amway's series of products all have hesperidin added. The main active ingredient of the popular health care product Vitality 50 in the United States is also hesperidin. (2) As an additive for some cosmetics, such as CLARINS' Chemicalbook, which contains hesperidin in many night creams. (3) In Japan, it is also used in food as an additive with the effect of vitamin P. In my country, hesperidin is mainly used as a drug raw material. The main therapeutic effects of related drugs include stomachic, expectorant, antitussive, wind-repellent, diuretic, anti-reflux and stomach pain relief.
