epicatechin 90% green tea extract epicatechin

Epicatechin: A Potent Natural Flavonoid for Antioxidant Support, Metabolic Health, and Cardiovascular Protection Epicatechin is a naturally occurring flavanol compound with the molecular formula C15H14O6, known for its white crystalline appearance and high solubility in water and methanol. As a key member of the catechin family—including epigallocatechin (EGC), catechin gallate (CG), epicatechin gallate (ECG), and epigallocatechin gallate (EGCG)—epicatechin stands out due to its unique stereochemistry and bioactive potential. Found in traditional Chinese medicinal herbs such as Polygonum multiflorum, Millettia reticulata, and Euonymus japonicus, it also appears in functional foods like red wine, grape seeds, litchi, and propolis. This polyphenolic compound plays a critical role in quality control of herbal formulations such as catechu granules, Weimaining capsules, and Qili powder, making it an essential biomarker for standardization. Key Features: - Naturally derived from tea leaves and plant-based sources - High antioxidant capacity through free radical scavenging - Supports metabolic balance by improving insulin sensitivity - Demonstrated cardiovascular protective effects - Exhibits anti-inflammatory and neuroprotective properties - Non-ester type catechin with cis configuration at C-ring positions Detailed Description: The molecular structure of epicatechin features three interconnected rings—A, B, and C—that form a low-symmetry polycyclic scaffold. The presence of multiple phenolic hydroxyl groups, particularly ortho-dihydroxy arrangements on the B ring (catechol moiety), enhances its ability to neutralize reactive oxygen species (ROS) and lipid peroxides. These structural elements are central to its potent antioxidant activity, which involves donating hydrogen atoms to stabilize free radicals, thereby preventing oxidative stress-related cellular damage. Research shows that epicatechin’s mechanism includes modulation of intracellular signaling pathways such as PI3K/Akt and MAPK/ERK, which regulate glucose uptake and inflammation. In animal models, daily supplementation with 20 mg/kg body weight significantly improved insulin resistance markers in fructose-fed rats by downregulating negative regulators like PKC, JNK, and PTP1B in adipose tissue. Beyond antioxidation, epicatechin contributes to cardiovascular wellness. Studies in hypercholesterolemic mice revealed a 27% reduction in atherosclerotic lesion formation compared to controls, without altering plasma cholesterol levels. This suggests targeted protection against severe vascular injury rather than general lipid-lowering effects. Additionally, epicatechin has shown promise in modulating immune responses and inhibiting tumor cell proliferation by interfering with the cell cycle, indicating potential applications in chronic disease prevention and health maintenance. Use Cases: Ideal for dietary supplements targeting metabolic health, heart function, and aging-related conditions. Suitable for individuals seeking natural compounds with proven physiological benefits in antioxidant defense, blood sugar regulation, and vascular integrity. Often included in nutraceutical blends designed for cognitive support, anti-aging skincare, and sports recovery formulas due to its ability to enhance endothelial function and reduce exercise-induced oxidative stress. User Feedback: Users report improved energy levels, clearer mental focus, and better post-meal blood sugar stability when incorporating epicatechin-rich extracts into their routine. Many appreciate its gentle action on digestion and overall well-being, especially those managing prediabetes or elevated inflammatory markers. Frequently Asked Questions: What makes epicatechin different from other catechins? Unlike EGCG or ECG, epicatechin lacks a gallic acid ester group at the 3’ position, making it a non-ester type catechin. Its cis-stereochemistry at the C-ring positions allows distinct interactions with biological targets compared to trans-isomers like catechin. How does epicatechin help with blood sugar management? By enhancing insulin signaling pathways in peripheral tissues and reducing oxidative stress in adipose tissue, epicatechin improves insulin sensitivity and reduces systemic inflammation linked to insulin resistance. Is epicatechin safe for long-term use? Yes, studies in both animals and humans indicate good tolerability at recommended doses, with no significant adverse effects reported over extended periods. Storage at 2–8°C preserves its potency and prevents degradation.