Salinomycin powder CAS 53003-10-4 Feed Additives Salinomycin

Salinomycin: A Potent Ionophore Antibiotic for Livestock Health and Emerging Cancer Research Salinomycin is a naturally derived polyether ionophore antibiotic widely recognized for its exceptional efficacy in controlling coccidiosis and supporting animal growth performance. Originally developed as a feed additive, this compound has gained global attention not only for its role in veterinary medicine but also for its promising applications in oncology research. With a molecular formula of C42H69O11Na and a CAS number of 53003-10-4, Salinomycin stands out due to its rapid excretion, minimal residue levels, and low risk of developing drug resistance—making it a preferred choice among livestock producers worldwide. Key Features: - Broad-spectrum activity against Gram-positive bacteria and coccidia - High bioavailability and quick elimination from the body - Effective at low inclusion rates in feed formulations - Supports gut health, improves feed efficiency, and enhances weight gain - Demonstrated anti-cancer potential targeting cancer stem cells in preclinical models In-depth Description: This white to light yellow crystalline powder exhibits excellent stability when incorporated into feed matrices through advanced processing techniques. It dissolves readily in organic solvents such as acetone, chloroform, benzene, and methanol, while remaining nearly insoluble in water—a characteristic that ensures targeted delivery within the gastrointestinal tract of animals. The compound functions by forming ion channels across microbial membranes, disrupting electrolyte balance and ultimately inhibiting pathogen proliferation. Unlike traditional antibiotics, Salinomycin does not promote cross-resistance, which makes it an ideal component in sustainable antimicrobial strategies for poultry and swine production systems. For poultry, especially chickens, Salinomycin effectively prevents intestinal coccidiosis caused by Eimeria species, reducing mortality and diarrhea incidence. In pigs, it acts as a growth promoter during weaning and finishing phases, improving feed conversion ratios and overall health. Its mechanism supports better nutrient absorption and reduces reliance on conventional antibiotics, aligning with modern farming practices focused on animal welfare and environmental stewardship. Usage Scenarios: Ideal for use in commercial broiler and layer operations where coccidiosis control is critical. Also suitable for pig farms aiming to boost early growth and reduce post-weaning diarrhea. Veterinarians and animal nutritionists often recommend Salinomycin as part of integrated parasite management programs. Additionally, researchers exploring novel therapeutic agents have identified Salinomycin’s ability to selectively target breast cancer stem cells in murine models—with reported potency up to 100 times greater than Taxol (paclitaxel). This dual functionality positions Salinomycin at the intersection of veterinary science and biomedical innovation. User Feedback: Farmers globally report significant improvements in flock uniformity, reduced medication costs, and enhanced productivity after incorporating Salinomycin into daily rations. Animal health professionals appreciate its safety profile, particularly the absence of harmful residues in meat or eggs. Researchers note its unique mode of action and potential as a lead compound for future anticancer therapies, especially in cancers driven by resistant stem cell populations. Frequently Asked Questions: How is Salinomycin administered? It is typically mixed into complete feed at recommended dosages based on species and age group—50–70 grams per ton for chickens, 25–75 grams per ton for pigs, and 10–30 grams per ton for cattle. Is it safe for human consumption? No, Salinomycin is intended exclusively for animal use and should never be consumed by humans. It is not approved for human medical use outside of controlled clinical trials. What are the benefits over other ionophores? Compared to monensin or lasalocid, Salinomycin offers superior efficacy against avian coccidia and lower toxicity in swine, making it more versatile across different livestock species. Can it help reduce antibiotic use in farming? Yes, by controlling bacterial pathogens and enhancing gut integrity, Salinomycin allows producers to minimize the need for therapeutic antibiotics, contributing to responsible antimicrobial stewardship.